Pathology is a rapidly evolving field that provides the scientific foundation for clinical medicine and plays a pivotal role in patient care as well as basic and translational research. Our expertise in evaluating the morphology and mechanisms of disease serves as a bridge between basic sciences and patient care. The Department of Anatomical and Cellular Pathology in the Chinese university of Hong Kong strives to provide state of the art clinical diagnostic services, innovative research, and motivating education and training programs to a diverse spectrum of learners. Our Pathology Core facility is dedicated to providing laboratory services that includes all aspects of anatomical and molecular pathology, biorepository and animal center in support of basic, translational, and clinical research. Through collaborative multidisciplinary research we strives to transform our knowledge of the mechanisms of disease into the best quality of healthcare to the community.
Research area
Grant & Donation
| Scheme | Project Title | Year Awarded |
|---|---|---|
| Health and Medical Research Fund | Investigation of the utility of CDK4/6 inhibitors in lung adenocarcinoma with patient-derived organoids: a preclinical, translational study (09203216) | 07/01/2022 to 30/06/2025 |
| Health and Medical Research Fund | Targeting Synthetic Lethality Interaction of MTAP and PRMT5/MAT2A Axis in Primary, Recurrent and Metastatic Nasopharyngeal Carcinoma | 01/08/2023 to 31/07/2025 |
| General Research Fund | Development of Aptamer-Drug Conjugates (ApDCs) for treatment of Epstein-Barr virus (EBV)-associated nasopharyngeal carcinoma | 01/01/2023 to 31/12/2025 |
| Health and Medical Research Fund | Development and Preclinical Evaluation of a Novel Macrophage-Myofibroblast Transition Targeted Therapy for Chronic Kidney Disease | 01/08/2023 to 31/07/2026 |
| Passion for Perfection Scheme | Development of a Highly Efficient Virus-free Gene Knock-In System for CAR-T/NK Cell Engineering: USMB-KI | 01/04/2023 to 31/03/2028 |
| Health and Medical Research Fund | Artificial intelligence image analysis in breast cancer detection and immunohistochemistry scoring. | 01/08/2021 to 31/07/2023 |
| General Research Fund | Elucidating the roles of PRMT5 in regulating cellular differentiation and EBV latency in nasopharyngeal carcinoma | 01/10/2021 to 30/09/2024 |
| Health and Medical Research Fund | Digital image analysis of tumor infiltrating lymphocyte and tertiary lymphoid organ in breast cancer | 10/01/2021 to 30/09/2024 |
| Health and Medical Research Fund | Restoration of p53 expression to facilitate CytoLytic Virus Activation (CLVA) therapy for targeting Epstein-Barr virus (EBV)-associated cancers. | 11/01/2021 to 31/10/2024 |
| Health and Medical Research Fund | Molecular Stratification of Adult Gliomas for Prognostication Using Next Generation Seqencing Approach | 01/07/2020 to 30/06/2022 |
Selected Publications
- Tang PC, Chung JY, Xue VW, Xiao J, Meng XM, Huang XR, Zhou S, Chan AS, Tsang AC, Cheng AS, Lee TL, Leung KT, Lam EW, To KF, Tang PM, Lan HY. Smad3 Promotes Cancer-Associated Fibroblasts Generation via Macrophage-Myofibroblast Transition. Adv Sci (Weinh). 2022 Jan;9(1):e2101235. doi: 10.1002/advs.202101235. Epub 2021 Nov 17. PMID: 34791825; PMCID: PMC8728853.
- Wang Y, Chen H, Liu W, Yan H, Zhang Y, Cheung AHK, Zhang J, Chen B, Liang L, Zhou Z, Wong CC, Wu WKK, Chan MWY, Cheng ASL, Ma BBY, Yu J, Lo KW, To KF, Kang W. MCM6 is a critical transcriptional target of YAP to promote gastric tumorigenesis and serves as a therapeutic target. Theranostics. 2022 Sep 6;12(15):6509-6526. doi: 10.7150/thno.75431. PMID: 36185598; PMCID: PMC9516235.
- Wang Y, Chen H, Yu J, Kang W, To KF. Recent insight into the role and therapeutic potential of YAP/TAZ in gastrointestinal cancers. Biochim Biophys Acta Rev Cancer. 2022 Sep;1877(5):188787. doi: 10.1016/j.bbcan.2022.188787. Epub 2022 Aug 28. PMID: 36041574.
- Tang PC, Chung JY, Liao J, Chan MK, Chan AS, Cheng G, Li C, Huang XR, Ng CS, Lam EW, Zhang D, Ho YP, To KF, Leung KT, Jiang X, Ko H, Lee TL, Lan HY, Tang PM. Single-cell RNA sequencing uncovers a neuron-like macrophage subset associated with cancer pain. Sci Adv. 2022 Oct 7;8(40):eabn5535. doi: 10.1126/sciadv.abn5535. Epub 2022 Oct 7. PMID: 36206343; PMCID: PMC9544324.
- Bruce JP, To KF, Lui VWY, Chung GTY, Chan YY, Tsang CM, Yip KY, Ma BBY, Woo JKS, Hui EP, Mak MKF, Lee SD, Chow C, Velapasamy S, Or YYY, Siu PK, El Ghamrasni S, Prokopec S, Wu M, Kwan JSH, Liu Y, Chan JYK, van Hasselt CA, Young LS, Dawson CW, Paterson IC, Yap LF, Tsao SW, Liu FF, Chan ATC, Pugh TJ, Lo KW. Whole-genome profiling of nasopharyngeal carcinoma reveals viral-host co-operation in inflammatory NF-κB activation and immune escape. Nat Commun. 2022 Jul 27;13(1):4353. doi: 10.1038/s41467-022-32156-9.
- Chen B, Chan WN, Mui CW, Liu X, Zhang J, Wang Y, Cheung AHK, Chan AKY, Chan RCK, Leung KT, Dong Y, Pan Y, Ke H, Liang L, Zhou Z, Wong CC, Wu WKK, Cheng ASL, Yu J, Lo KW, To KF, Kang W. STK3 promotes gastric carcinogenesis by activating Ras-MAPK mediated cell cycle progression and serves as an independent prognostic biomarker. Mol Cancer. 2021 Nov 12;20(1):147. doi: 10.1186/s12943-021-01451-2. PMID: 34772410; PMCID: PMC8588685.
- Tang PM, Zhang YY, Hung JS, Chung JY, Huang XR, To KF, Lan HY. DPP4/CD32b/NF-κB Circuit: A Novel Druggable Target for Inhibiting CRP-Driven Diabetic Nephropathy. Mol Ther. 2021 Jan 6;29(1):365-375. doi: 10.1016/j.ymthe.2020.08.017. Epub 2020 Sep 5. PMID: 32956626; PMCID: PMC7790911.
- Tang PM, Zhang YY, Xiao J, Tang PC, Chung JY, Li J, Xue VW, Huang XR, Chong CC, Ng CF, Lee TL, To KF, Nikolic-Paterson DJ, Lan HY. Neural transcription factor Pou4f1 promotes renal fibrosis via macrophage-myofibroblast transition. Proc Natl Acad Sci U S A. 2020 Aug 25;117(34):20741-20752. doi: 10.1073/pnas.1917663117. Epub 2020 Aug 11. Erratum in: Proc Natl Acad Sci U S A. 2022 Mar 8;119(10):e2200781119. PMID: 32788346; PMCID: PMC7456094.
- Ding X, He M, Chan AWH, Song QX, Sze SC, Chen H, Man MKH, Man K, Chan SL, Lai PBS, Wang X, Wong N. Genomic and Epigenomic Features of Primary and Recurrent Hepatocellular Carcinomas. Gastroenterology. 2020 May 16:S0016-5085(20)30659-4. doi: 10.1053/j.gastro.2019.09.056. Epub ahead of print. PMID: 32428506.
- Tsang CM, Lui VWY, Bruce JP, Pugh TJ, Lo KW. Translational genomics of nasopharyngeal cancer. Semin Cancer Biol. 2020 Apr;61:84-100. doi: 10.1016/j.semcancer.2019.09.006. Epub 2019 Sep 12. PMID: 31521748.
